Behavioral effects of amylin injected intracerebroventricularly in the rat.
Peptides
; 17(4): 589-91, 1996.
Article
em En
| MEDLINE
| ID: mdl-8804066
ABSTRACT
Amylin is a peptide of pancreatic origin that has been reported to possess high-affinity binding sites in the brain and to affect central dopaminergic and serotonergic neurotransmission. Administered ICV the peptide induced a dose-dependent decrease of locomotor activity without affecting grooming and sniffing. At a dose of 5 micrograms/ rat, it antagonized the hypermotility and stereotypies induced by s.c. injection of amphetamine (2 mg/kg) or of the dopamine receptor agonist, apomorphine (250 mg/kg). Amylin did not change significantly the effect of haloperidol (0.5 mg/kg, s.c.) on locomotor activity, grooming, and sniffing. Moreover, the peptide did not modify the locomotor behavior of animals injected with the 5-HT2 antagonist, ritanserin (2 mg/kg, s.c.). These results suggest that amylin may exert motor effects, probably by interfering with central dopaminergic neurotransmission.
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Base de dados:
MEDLINE
Assunto principal:
Comportamento Estereotipado
/
Dopamina
/
Ventrículos Cerebrais
/
Amiloide
/
Atividade Motora
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article