Cytogenetic effect of some insecticides in mouse spleen.
J Appl Toxicol
; 16(1): 1-3, 1996.
Article
em En
| MEDLINE
| ID: mdl-8821669
ABSTRACT
Several insecticides were tested for their ability to induce chromosomal aberrations in mouse spleen. They were injected i.p. in doses representing approximately 1/8-1/10 of the respective LD50 values. Doses were DDT, 5.5 mg kg-1 body wt.; malathion, 30 mg kg-1 body wt.; Dursban, 4 mg kg-1 body wt.; Sevin, 7 mg kg-1 body wt.; and Lannate, 1 mg kg-1 body wt. 'Mitomycin C' at a dose of 1 mg kg-1 body wt. was used as a positive control. Mice were sacrificed 6, 24 and 48 h after treatment. DDT, malathion, dursban and lannate caused maximum chromosomal aberrations 24 h after injection, whereas Sevin induced its maximum effect 6 h after the treatment. All the insecticides induced statistically significant chromosomal aberrations even after excluding the number of metaphases with gaps. The results indicate genotoxicity in mouse spleen cells.
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Base de dados:
MEDLINE
Assunto principal:
Baço
/
Aberrações Cromossômicas
/
Inseticidas
/
Mutagênicos
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article