Modulation of immune responses by bovine beta-casein.
Immunol Cell Biol
; 74(4): 323-9, 1996 Aug.
Article
em En
| MEDLINE
| ID: mdl-8872182
ABSTRACT
The present reports the influence of bovine beta-casein on in vitro and in vivo immune responses. Bovine beta-casein showed an inhibitory effect on ovine neutrophil chemotaxis but had an enhancing effect on superoxide production by neutrophils. In response to mitogenic stimulation, the proliferative response of both T and B lymphocytes was significantly enhanced by beta-casein. While beta-casein had no significant effects on IFN gamma production by ovine blood lymphocytes, and TNF alpha production and MCH Class II antigen expression by ovine bronchoalveolar macrophages, it enhanced IL-1 beta production by the macrophages, beta-casein also had no influence on bovine NK cell activity against a virally-infected cell line. Interestingly, beta-casein was found to reduce the adjuvant effect of matrix immune stimulating complexes (ISCOM) on anti-ovalbumin antibody response in mice when given intramuscularly. Taken together, the results suggest that bovine beta-casein had selective modulating effects in vitro on both innate and adaptive immune responses in ruminants, whereas systemic administration of beta-casein, that might have a depressive effect on adjuvant activity, requires further study.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
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Células Matadoras Naturais
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Linfócitos T
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Caseínas
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Antígenos de Histocompatibilidade Classe II
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Citocinas
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Neutrófilos
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article