Induction chemotherapy followed by allogeneic bone marrow transplantation or aggressive consolidation chemotherapy in childhood acute myeloblastic leukemia. A prospective study from the French Society of Pediatric Hematology and Immunology (SHIP).
Hematol Cell Ther
; 38(2): 169-76, 1996 Apr.
Article
em En
| MEDLINE
| ID: mdl-8931998
ABSTRACT
In the LAME89/91 protocol, children with acute myeloid leukemia (AML) who achieved complete remission (CR) after induction chemotherapy, were treated either with allogeneic bone marrow transplantation (BMT) if they had an HLA-compatible related donor or with chemotherapy including high-dose cytarabine. The objectives of this study were to describe the overall results of this strategy and to compare the two post-remission arms. Two hundred and thirty-one children were enrolled in the protocol. Induction chemotherapy consisted of a combination of cytarabine and mitoxantrone. A CR was achieved in 204 children (88%).
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Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide
/
Transplante de Medula Óssea
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article