Further evidence for a common mechanism for shedding of cell surface proteins.
FEBS Lett
; 401(2-3): 235-8, 1997 Jan 20.
Article
em En
| MEDLINE
| ID: mdl-9013894
ABSTRACT
Pro-TNF alpha, Steel factor, type II IL-1R and IL-2R alpha were expressed in COS-7 cells and the generation of their soluble forms was examined. The release of all four proteins was strongly stimulated by the phorbol ester PMA and completely blocked by a hydroxamate-based inhibitor of metalloproteases. COS-7 cell membranes were found to cleave various synthetic pro-TNF alpha peptides with the same specificity as a partially purified TNF alpha converting enzyme purified from human monocytic cells, suggesting that the same enzyme may be responsible for at least some of the COS-7 cell shedding activity.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article