Recurrent infectious diseases in human CD53 deficiency.
Clin Diagn Lab Immunol
; 4(2): 229-31, 1997 Mar.
Article
em En
| MEDLINE
| ID: mdl-9067662
ABSTRACT
We report a familiar syndrome of recurrent heterogeneous infectious diseases, caused by bacteria, fungi, and viruses, which has as its only detectable defect the lack of CD53 antigen expression in neutrophils. All other assays ruled out known causes of recurrent infectious diseases due to either leukocyte adhesion or phagocytosis defects. CD53 belongs to the transmembrane-4 superfamily of proteins, which are a novel group of membrane proteins implicated in growth regulation and cell motility and possibly cell adhesion. We postulate that defects in these membrane proteins can be clinically manifested as complex recurrent infections.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antígenos de Diferenciação de Linfócitos T
/
Antígenos CD
/
Doenças Transmissíveis
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Síndromes de Imunodeficiência
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article