Inhibition of nitric oxide synthase causes cardiac phenotypic modulation in rat.
Eur J Pharmacol
; 322(1): 59-62, 1997 Mar 12.
Article
em En
| MEDLINE
| ID: mdl-9088871
ABSTRACT
Cardiac gene expressions of collagen and contractile proteins were examined in rats treated with a nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), for 3 weeks. The rats became hypertensive, which caused left ventricular hypertrophy. Among the mRNAs examined, beta-myosin heavy chain was increased and alpha-myosin heavy chain was decreased in both left and right ventricles, whereas skeletal alpha-actin and atrial natriuretic polypeptide were increased in the left ventricle only. Furthermore, coadministration of losartan with L-NAME lowered blood pressure and caused regression of left ventricular hypertrophy, but did not affect beta- and alpha-myosin heavy chain mRNA levels, indicating that L-NAME directly regulates beta- and alpha-myosin heavy chain mRNA.
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Base de dados:
MEDLINE
Assunto principal:
Óxido Nítrico Sintase
/
NG-Nitroarginina Metil Éster
/
Inibidores Enzimáticos
/
Coração
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article