[Involvement of enhanced glutamate release in halogenated volatile anesthetic-induced excitation in mouse brain].
Masui
; 46(3): 338-43, 1997 Mar.
Article
em Ja
| MEDLINE
| ID: mdl-9095605
The present experiments aimed to elucidate the mechanisms of excitatory effects of volatile anesthetics. In ddN mice, enflurane (2% in air), sevoflurane (2%) or isoflurane (1.2%) induced opisthotonus. In ddY mice, a halogenated ethane, tetrachlorodifluoroethane (CCl2FCCl2F:DF-112, 2%) induced tonic-clonic convulsion. These CNS excitatory effects were suppressed by pretreatment with an N-methyl-D-aspartate antagonist, MK-801 (0.5mg.kg-1). Halogenated volatile anesthetics (enflurane, sevoflurane, isoflurane and halothane) increased glutamate release from synaptosomes of the mouse cerebral cortex at concentrations corresponding to those used clinically. The convulsive gas, DF-112, released glutamate more potently than the anesthetics. These data suggest the involvement of enhanced glutamate release in the mechanisms of excitatory effects of halogenated volatile anesthetics.
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Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Espasmo
/
Clorofluorcarbonetos
/
Ácido Glutâmico
/
Anestésicos Inalatórios
/
Halogênios
/
Éteres Metílicos
Idioma:
Ja
Ano de publicação:
1997
Tipo de documento:
Article