Cohort study of association of risk of breast cancer with cyst type in women with gross cystic disease of the breast.
BMJ
; 314(7085): 925-8, 1997 Mar 29.
Article
em En
| MEDLINE
| ID: mdl-9099114
ABSTRACT
OBJECTIVE:
To assess correlation between type of breast cyst and risk of breast cancer in women with gross cystic disease of the breast.DESIGN:
Cohort study of women with breast cysts aspirated between 1983 and 1993 who were followed up until December 1994 for occurrence of breast cancer.SETTING:
Major cancer prevention centre.SUBJECTS:
802 women with aspirated breast cysts. MAIN OUTCOMEMEASURES:
Type of breast cyst based on cationic content of cyst fluid type I (potassiumsodium ratio > 1.5), type II (potassiumsodium ratio < 1.5), or mixed (both types). Subsequent occurrence and type of breast cancer.RESULTS:
After median follow up of six years (range 2-12 years) 15 cases of invasive breast cancer and two ductal carcinomas in situ were diagnosed in the cohort 12 invasive cancers (and two carcinomas in situ) among the 417 women with type I cysts, two cancers among the 325 women with type II cysts, and one among the 60 women with mixed cysts. The incidence of breast cancer in women with type I cysts was significantly higher than that in women with type II cysts (relative risk 4.62 (95% confidence interval 1.26 to 29.7)). These results were confirmed after adjustment for several risk factors for breast cancer (relative risk 4.24 (1.12 to 27.5)).CONCLUSIONS:
The increased risk of breast cancer of women with breast cysts seems to be concentrated among women with type I breast cysts.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Doença da Mama Fibrocística
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article