p53 is not required for regulation of apoptosis or radioprotection by interleukin-3.
Blood
; 89(8): 2717-22, 1997 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-9108389
ABSTRACT
Primary interleukin-3 (IL-3)-dependent mast cell cultures from bone marrow of p53-null mice and littermate controls were established. Both p53-null and wild-type cells entered apoptosis on IL-3 removal, showing that p53 is not required for entry into apoptosis after factor deprivation. After X-irradiation, a lower proportion of the p53-null than wild-type cells underwent G2 arrest, but their radiosensitivity was similar. An IL-3-dependent cell line expressing wild-type p53 was used to show that cells die at a fixed time after X-irradiation rather than from a specific cell cycle point.
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Base de dados:
MEDLINE
Assunto principal:
Tolerância a Radiação
/
Proteína Supressora de Tumor p53
/
Interleucina-3
/
Apoptose
/
Mastócitos
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article