Modulation of lipoxygenase activity by bacterial hopanoids.
J Nat Prod
; 60(4): 397-8, 1997 Apr.
Article
em En
| MEDLINE
| ID: mdl-9134748
ABSTRACT
Tetrahydroxybacteriohopane (1), a bacterial hopanoid, inhibited soybean 15-lipoxygenase with an IC50 of about 10 microM. After per-O-acetylation of 1 no inhibition of the 15-lipoxygenase was observed. Two other bacterial hopanoids, tetrahydroxybacteriohopane glucosamine (2) and tetrahydroxybacteriohopane ether (3), stimulated the activity of soybean 15-lipoxygenase. The activities of two other arachidonic acid-metabolizing enzymes, human 5-lipoxygenase and prostaglandin H synthase, were unaffected by 1.
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Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Inibidores de Lipoxigenase
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article