L-alpha-aminoadipate reduces glutamate release from brain tissue exposed to combined oxygen and glucose deprivation.
J Cereb Blood Flow Metab
; 17(5): 567-70, 1997 May.
Article
em En
| MEDLINE
| ID: mdl-9183295
ABSTRACT
The effect of the glutamate analogue L-alpha-aminoadipate (alpha AA) on the release of glutamate and gamma-aminobutyric acid (GABA) from rat hippocampal slices was investigated in vitro. Oxygen/glucose deprivation caused a large release of glutamate and GABA. alpha AA added during energy deprivation reduced the glutamate release in a dose-dependent manner (56% reduction at 5 mM), whereas GABA release was unchanged. We speculate that ischemic glutamate release from the brain is mediated by a low affinity transport mechanism that is blocked by alpha AA.
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Base de dados:
MEDLINE
Assunto principal:
Ácido Glutâmico
/
Glucose
/
Ácido 2-Aminoadípico
/
Hipocampo
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article