1 alpha,25-dihydroxyvitamin D3 induces very low density lipoprotein receptor mRNA expression in HL-60 cells in association with monocytic differentiation.
Atherosclerosis
; 133(1): 45-9, 1997 Aug.
Article
em En
| MEDLINE
| ID: mdl-9258406
ABSTRACT
Expression of VLDL receptor mRNA during differentiation of HL-60 cells was investigated by Northern analysis. The expression induced in 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25(OH)2D3)-treated cells was 3 times that in untreated cells, while LDL receptor mRNA expression was unchanged. VLDL receptor mRNA levels were not changed in macrophages caused to differentiate from HL-60 cells by treatment with phorbol 12-myristate 13-acetate (PMA). Treatment of sarcoma cells which possess the vitamin D receptor (MG-63 cell line) with 1 alpha,25(OH)2D3 did not affect VLDL receptor mRNA levels. Therefore, 1 alpha,25(OH)2D3 induces VLDL receptor mRNA in HL-60 cells through differentiation-dependent mechanisms.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Calcitriol
/
RNA Mensageiro
/
Receptores de LDL
/
Monócitos
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article