Rat kidney thromboxane synthase: cDNA cloning and gene expression regulation in hydronephrotic kidney.
Prostaglandins
; 53(6): 423-31, 1997 Jun.
Article
em En
| MEDLINE
| ID: mdl-9261862
ABSTRACT
We isolated a rat homolog of thromboxane (TX) synthase cDNA (-1.8 kb) from the kidney with a fragment of human TX synthase cDNA amplified by polymerase chain reaction with placenta cDNA as a template. Northern blot analysis has shown that rat TX synthase gene is expressed abundantly in lung, liver, and uterus; moderately in kidney. TX synthase mRNA expression was up-regulated in hydronephrotic kidney made by ureter ligation. In conclusion, we have revealed the structure of rat kidney TX synthase. Up-regulation of renal TX synthase, which may cause stimulation of TX synthesis, is possibly implicated in the tissue injury in hydronephrotic kidney.
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Base de dados:
MEDLINE
Assunto principal:
Tromboxano-A Sintase
/
Regulação da Expressão Gênica
/
Clonagem Molecular
/
DNA Complementar
/
Hidronefrose
/
Rim
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article