Effect of amylin in various experimental models of gastric ulcer.
Eur J Pharmacol
; 332(2): 209-13, 1997 Aug 06.
Article
em En
| MEDLINE
| ID: mdl-9286623
ABSTRACT
Subcutaneous administration of amylin (20-40 micrograms/kg) prevented, in a dose-dependent manner, reserpine- and serotonin-induced gastric damage, but the anti-ulcer effect was not present when lesions were induced by pylorus ligation. The protective effect of amylin was inhibited by pretreatment with capsicin as well as CGRP-(8-37), a calcitonin gene-related peptide (CGRP) and amylin receptor antagonist, and was significantly reduced by domperidone, a dopamine D2 receptor antagonist, or neostigmine, an inhibitor of acetylcholinesterase. Our data suggest that the gastroprotective activity of amylin in some experimental models of gastric ulcers involves capsaicin-sensitive fibers and CGRP receptors. Moreover, the peptide interferes, at least in part, with the dopaminergic and parasympathetic systems.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Úlcera Gástrica
/
Amiloide
/
Antiulcerosos
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article