Remission in hairy cell leukemia-variant following splenic radiotherapy alone.
Leuk Lymphoma
; 26(3-4): 395-8, 1997 Jul.
Article
em En
| MEDLINE
| ID: mdl-9322903
ABSTRACT
The therapeutic approach to hairy cell leukemia (HCL) is in some instances still debated. A variant form of HCL (HCL-V) characterized by high white cell count, splenomegaly, hypercellular and aspirable bone marrow has been described; differential diagnosis often arises with some other B-cell disorders which also show circulating hairy or villous lymphocytes. Conventional treatment for HCL is often less effective in HCL-V. In this report we describe a case with features consistent with HCL-variant treated with splenic radiotherapy. We not only obtained an hematological response but also the near total disappearance of bone marrow infiltration, compatible with a clinical complete remission. Clinical and biological implications of this phenomenon are discussed on the basis of this unexpected therapeutic result, obtained with splenic radiotherapy alone.
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Base de dados:
MEDLINE
Assunto principal:
Baço
/
Leucemia de Células Pilosas
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article