Indomethacin in the management of elevated intracranial pressure: a review.
J Neurotrauma
; 14(9): 637-50, 1997 Sep.
Article
em En
| MEDLINE
| ID: mdl-9337126
ABSTRACT
Elevated intracranial pressure occurs frequently in patients with severe head injury. A number of studies in recent years suggest that indomethacin may be useful in the management of elevated intracranial pressure. Indomethacin acts primarily by reducing cerebral blood flow and decreasing cerebral edema following head injury. This review summarizes the basic and clinical studies of the effects of indomethacin on cerebral blood flow, brain edema, and intracranial pressure. The pharmacology of indomethacin, and issues for future investigation in the use of indomethacin in severe head injury, are discussed.
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Base de dados:
MEDLINE
Assunto principal:
Edema Encefálico
/
Pressão Intracraniana
/
Circulação Cerebrovascular
/
Indometacina
/
Inibidores de Ciclo-Oxigenase
/
Traumatismos Craniocerebrais
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article