New treatments using alginate in order to reduce the calcification of bovine bioprosthetic heart valve tissue.
J Biomater Sci Polym Ed
; 8(12): 919-30, 1997.
Article
em En
| MEDLINE
| ID: mdl-9399142
ABSTRACT
Calcification limits the functional lifetime of cardiac valve substitutes fabricated from glutaraldehyde preserved bovine pericardium. Host factors, mainly younger age, and implant factors, mainly glutaraldehyde cross-linking, are implicated in the calcification process. Glutaraldehyde cross-linking is believed to activate the potential sites in the tissues for biocalcification. In the present work, we investigated the possibility of using alginate azide (AA) instead of glutaraldehyde for the preservation of pericardial tissues in order to enhance the durability of bioprosthetic heart valves. Grafting with poly(GMA-BA) copolymer to the alginate azide cross-linked pericardial (AACPC) tissue was carried out to obtain better stability, strength, and anticalcification properties. The strength property and thermal stability of the AA cross-linked tissues were studied. Calcification studies in rat subdermal models reveal that AA cross-linking reduces the calcification to negligible levels. After 30 days implantation, the calcium content was found to be 10.4 +/- 1.2 and 6.1 +/- 0.3 micrograms mg-1 for untreated AACPC and polymer grafted AACPC, respectively, compared to a value of 100 +/- 1.2 micrograms mg-1 calcium recorded for control glutaraldehyde cross-linked pericardial (GCPC) tissues.
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Base de dados:
MEDLINE
Assunto principal:
Materiais Biocompatíveis
/
Bioprótese
/
Calcinose
/
Próteses Valvulares Cardíacas
/
Alginatos
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article