Capsular polysaccharide-fimbrial protein conjugate vaccine protects against Porphyromonas gingivalis infection in SCID mice reconstituted with human peripheral blood lymphocytes.
Infect Immun
; 66(1): 391-3, 1998 Jan.
Article
em En
| MEDLINE
| ID: mdl-9423888
ABSTRACT
The effect of immunization with either a Porphyromonas gingivalis fimbrial protein, a capsular polysaccharide, or a capsular polysaccharide-fimbrial protein conjugate vaccine were compared in hu-PBL-SCID mice. A significantly higher human immunoglobulin G antibody response and the highest degree of in vivo protection against bacterial challenge was observed in the group immunized with the conjugate vaccine. It was concluded that capsular polysaccharide-fimbrial protein conjugate from P. gingivalis could potentially be developed as a vaccine against periodontal infection by P. gingivalis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos Bacterianos
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Infecções por Bacteroidaceae
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Vacinas Conjugadas
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Porphyromonas gingivalis
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Adesinas Bacterianas
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article