Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid.
Vision Res
; 37(24): 3445-51, 1997 Dec.
Article
em En
| MEDLINE
| ID: mdl-9425521
ABSTRACT
Transient retinal ischemia results in a delayed cell death of the inner retinal layers. This study demonstrates that this ischemic cell death occurs, at least in part, through apoptosis. The general endonuclease inhibitor, aurintricarboxylic acid, protected rat retinal cells from ischemic cell damage when administered before the onset of ischemia and, more importantly, when administered 6 hr after the insult. Thus, the demonstration that transient retinal ischemia results in cell damage as a result of apoptosis opens new therapeutic strategies aimed at lessening retinal damage as a result of this process.
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Base de dados:
MEDLINE
Assunto principal:
Retina
/
Ácido Aurintricarboxílico
/
Apoptose
/
Isquemia
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article