Molecular cloning of avian matrix Gla protein.
Biochim Biophys Acta
; 1395(1): 47-9, 1998 Jan 07.
Article
em En
| MEDLINE
| ID: mdl-9434150
ABSTRACT
Matrix Gla protein plays an essential role in preventing the calcification of blood vessel walls, cartilage and other tissues. We report here the primary structure of chicken matrix Gla protein as deduced from the cDNA sequence. The avian protein exhibited the characteristic motifs previously identified in the mammalian proteins, but its amino acid sequence shared only 51-56% identity with the latter proteins. Moreover, a region proposed to function as binding site for gamma-carboxylase in the mammalian proteins was poorly conserved in the chicken protein. Our sequence data should be helpful in the design of mutational analyses which are intended to characterize functional interactions of matrix Gla proteins with other proteins.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Ligação ao Cálcio
/
Proteínas da Matriz Extracelular
/
DNA Complementar
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article