Dimethylsilane polyamines: cytostatic compounds with potentials as anticancer drugs.
Anticancer Drug Des
; 12(8): 621-33, 1997 Dec.
Article
em En
| MEDLINE
| ID: mdl-9448702
ABSTRACT
Several dimethylsilane tetramines [homologs of spermine with an Si(CH3)2 group in the central carbon chain], a carbon analog of the dimethylsilane tetramines [containing C(CH3)2 instead of Si(CH3)2] and a dimethylsilane hexamine were studied with regard to their cytotoxic activity and their ability to interact with double-stranded DNA. All polyamine analogs exerted cytostatic effects to several cell lines at micromolar concentrations. Their ability to condense DNA was comparable to and their ability to displace ethidium bromide from binding to DNA was superior to that of spermine. Their cytostatic effect was not correlated with the depletion of cellular spermidine concentrations. It is suggested that the new polyamine analogs act mainly by displacing spermidine from binding sites which are essential for the promotion of cell growth.
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Base de dados:
MEDLINE
Assunto principal:
Poliaminas
/
Silanos
/
Antineoplásicos
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article