Altered expression of c-erbB-2, DF3, b72.3, p53 and Ki-67 with progression and differentiation to two distinct histologic types of invasive carcinoma in the MCF10AT human xenograft model of proliferative breast disease.
Int J Oncol
; 12(2): 369-75, 1998 Feb.
Article
em En
| MEDLINE
| ID: mdl-9458364
ABSTRACT
Human breast epithelial MCF10AT cells form simple ducts in nude/beige mice which eventually become hyperplastic and sporadically progress to carcinomas. Altered immunohistochemical detection of c-erbB-2, DF3, B72.3, p53 and Ki-67 was observed with progression and differentiation to two distinct histologic types of invasive carcinoma. c-erbB-2 and DF3 were detected in 50% and 18% of lesions at the stage of atypical hyperplasia and expression increased to 78% and 54% in invasive adenocarcinomas. In contrast, a group of six unusual undifferentiated tumors with squamoid features did not express c-erbB-2 or DF3, but both B72.3 (4/6) and p53 (6/6) were detected.
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Base de dados:
MEDLINE
Assunto principal:
Adenocarcinoma
/
Neoplasias Mamárias Animais
/
Proteína Supressora de Tumor p53
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Receptor ErbB-2
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Antígeno Ki-67
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Antígenos de Neoplasias
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article