CD4+/CD45RA+ 'naive' T cells and immunological response to influenza virus vaccine in B-cell chronic lymphocytic leukaemia patients.
Acta Haematol
; 99(1): 18-21, 1998.
Article
em En
| MEDLINE
| ID: mdl-9490560
ABSTRACT
B-cell chronic lymphocytic leukaemia (B-CLL) is characterized by a high frequency of infections, including those of viral aetiology. Previous reports have demonstrated a specific immunologic response to influenza virus vaccine in B-CLL patients with normal IgG levels. In this study, we have evaluated different immunophenotypically defined B and T cell subsets in 18 B-CLL patients before immunization with killed-influenza-virus vaccine. A correlation between immunological response to vaccination and both absolute numbers of CD4+/CD45RA+ naive T cells and CD5- B cells was found. These data may suggest a supporting role of the CD4+/CD45RA+ T cell subset in the specific antibody response to vaccination with influenza virus vaccine in B-CLL patients.
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Base de dados:
MEDLINE
Assunto principal:
Vacinas contra Influenza
/
Leucemia Linfocítica Crônica de Células B
/
Linfócitos T CD4-Positivos
/
Subpopulações de Linfócitos T
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article