Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity.
Proc Natl Acad Sci U S A
; 95(6): 2950-5, 1998 Mar 17.
Article
em En
| MEDLINE
| ID: mdl-9501196
ABSTRACT
The centrosome plays an important role in maintenance of cell polarity and in progression through the cell cycle by determining the number, polarity, and organization of interphase and mitotic microtubules. By examining a set of 35 high grade human breast tumors, we show that centrosomes of adenocarcinoma cells generally display abnormal structure, aberrant protein phosphorylation, and increased microtubule nucleating capacity in comparison to centrosomes of normal breast epithelial and stromal tissues. These structural and functional centrosome defects have important implications for understanding the mechanisms by which genomic instability and loss of cell polarity develop in solid tumors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Adenocarcinoma
/
Centrossomo
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article