Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle.
Mamm Genome
; 9(3): 210-3, 1998 Mar.
Article
em En
| MEDLINE
| ID: mdl-9501304
ABSTRACT
We have determined the entire myostatin coding sequence for 32 double-muscled cattle sampled from ten European cattle breeds. Seven DNA sequence polymorphisms were identified, of which five would be predicted to disrupt the function of the protein, one is a conservative amino acid substitution, and one a silent DNA sequence variant. Four additional DNA sequence polymorphisms were identified in myostatin intronic sequences. In all but two breeds, all double-muscled animals were either homozygous or compound heterozygotes for one of the five loss-of-function mutations. The absence of obvious loss-of-function mutations in the coding sequence of the two remaining breeds points either towards additional mutations in unexplored segments of the gene, or towards locus heterogeneity of double-muscling.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Transformador beta
/
Doenças Musculoesqueléticas
/
Músculo Esquelético
/
Alelos
/
Mutação
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article