Increased plasma amyloid beta protein 1-42 levels in Down syndrome.
Neurosci Lett
; 241(1): 13-6, 1998 Jan 23.
Article
em En
| MEDLINE
| ID: mdl-9502204
ABSTRACT
Amyloid beta protein 1-40 (A beta40) and A beta42 levels were quantitated in plasma from 43 persons with Down syndrome (DS; 26-68 years of age), 43 age-matched normal controls, and 19 non-DS mentally retarded (MR) persons (26-91 years of age) by using a sandwich enzyme linked immunosorbent assay. A beta40 levels were higher in DS and MR than controls, but were similar between DS and MR groups. A beta42 levels were higher in DS than controls or MR persons. The ratios of A beta42/A beta40 were higher in DS than controls or MR persons. The findings are consistent with those seen in DS brains.
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Peptídeos beta-Amiloides
/
Síndrome de Down
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article