Naturally occurring 2'-O-methylpurine nucleosides with hypotensive properties.
Cell Mol Life Sci
; 54(2): 125-8, 1998 Feb.
Article
em En
| MEDLINE
| ID: mdl-9539952
ABSTRACT
2'-O-Methylinosine (1) has been isolated for the first time and shown to be an intrinsic hypotensive principle. Its probable in vivo precursor, 2'-O-methyladenosine (3), showed stronger and even orally potent hypotensive activity. Resistance of the methyladenosine (3) against adenosine deaminase is thought to contribute to its long-lasting activity. The effect of both nucleosides (1 and 3) was not accompanied with any significant change in heart rate, which is often observed with adenosine.
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Base de dados:
MEDLINE
Assunto principal:
Nucleosídeos de Purina
/
Anti-Hipertensivos
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article