mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit.
Neurosci Lett
; 239(1): 49-53, 1997 Dec 12.
Article
em En
| MEDLINE
| ID: mdl-9547169
ABSTRACT
The expression of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B/epsilon2 (GRIN2B) in the human adult brain was assayed by in situ hybridisation, by using a specific cRNA probe. The full length GRIN2B cDNA was cloned and sequenced. It showed a 90% nucleotide conservation when compared to the rodent homologue. GRIN2B gene is expressed at high levels in the fronto-parieto-temporal cortex and hippocampus pyramidal cells and, at a lower extent, in the basal ganglia (amygdala and striatum). The cerebellar granule cells does not show any mRNA expression. The non-ubiquitous anatomical distribution of the GRIN2B mRNA in the central nervous system suggests that the gene could be involved in specific functions pertaining to the expressing cell groups.
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Química Encefálica
/
RNA Mensageiro
/
Receptores de N-Metil-D-Aspartato
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article