Retinal cytokine response in mouse alkali-burned eye.
Ophthalmic Res
; 30(3): 168-71, 1998.
Article
em En
| MEDLINE
| ID: mdl-9618720
ABSTRACT
The kinetics of inflammatory cytokines in sensory retina of mice with corneal alkali-burned eyes were examined. Retinal samples were collected from ICR mice with unburned and alkali-burned eyes from day 3 to day 14. Enzyme-linked immunosorbent assay was used to quantitate the expression levels of interleukin-1 alpha (IL-1 alpha), IL-1 beta and IL-6. Concentrations of IL-1 beta and IL-6 were significantly elevated at day 3 after alkali burn, and reduced to normal level by day 7. The concentration of IL-1 alpha was below assay sensitivity at all times. A significant elevation of IL-1 beta and IL-6 in the sensory retina may contribute to the retinal inflammatory response in the alkali-burned eyes. This is the first report suggesting that the retina is involved in the damage process of alkali burn.
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Base de dados:
MEDLINE
Assunto principal:
Retina
/
Queimaduras Químicas
/
Queimaduras Oculares
/
Interleucina-6
/
Interleucina-1
/
Lesões da Córnea
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article