Age-related alteration of the adenosine/dopamine balance in the rat striatum.
Brain Res
; 795(1-2): 297-300, 1998 Jun 08.
Article
em En
| MEDLINE
| ID: mdl-9622656
ABSTRACT
An antagonistic interaction between adenosine A2A- and dopamine D2-receptors has been described. Radioligand binding experiments showed a predominant reduction in the number of D2 vs. A2A-receptors in the striatum of aged compared to young rats. The A2A-receptor-mediated antagonistic modulation of D2-receptor binding remained unchanged in aged animals. In striatal homogenates a significant increase in adenosine and no change in dopamine content was found in aged vs. young rats. These results reveal the existence of an age-dependent imbalance of adenosine vs. dopamine in favor of adenosine, which involves both presynaptic and postsynaptic mechanisms.
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Dopamina
/
Adenosina
/
Corpo Estriado
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article