Pulmonary aspergillosis and invasive disease in AIDS: review of 342 cases.
Chest
; 114(1): 251-62, 1998 Jul.
Article
em En
| MEDLINE
| ID: mdl-9674477
ABSTRACT
Aspergillosis is an infrequent but commonly fatal infection among HIV-infected individuals. We review 342 cases of pulmonary Aspergillus infection that have been reported among HIV-infected patients, with a focus on invasive disease. Invasive pulmonary aspergillosis usually occurs among patients with <50 CD4 cells/mm3. Major predisposing conditions include neutropenia and steroid treatment. Fever, cough, and dyspnea are each present in >60% of the cases. BAL is often suggestive, but biopsy specimens are necessary for definite diagnosis. Amphotericin B is the mainstay of treatment and mortality is > 80%. Avoiding neutropenia and judicious use of steroids may be helpful in prevention. Aggressive diagnostic approach, early initiation of treatment, adequate dosing of antifungals, and close follow-up may improve the currently dismal prognosis.
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Base de dados:
MEDLINE
Assunto principal:
Aspergilose
/
Infecções Oportunistas Relacionadas com a AIDS
/
Pneumopatias Fúngicas
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article