Age-related brain changes in rhesus monkeys: a magnetic resonance spectroscopic study.
Neuroreport
; 9(9): 2127-30, 1998 Jun 22.
Article
em En
| MEDLINE
| ID: mdl-9674606
ABSTRACT
Brain metabolites were measured by proton magnetic resonance spectroscopy in five young (4-10 years of age) and six old (24-30 years of age) adult rhesus monkeys. The two age groups had similar levels of N-acetylaspartate and of choline relative to creatine, but the ratio of myo-inositol/creatine was higher in each old monkey than in any of the young animals. There was no significant relationship between the metabolite ratios and cognitive performance. The findings indicate that a consistent pattern of non-invasively detectable biochemical changes occurs in the brain with ageing. Whether these changes have functional significance in age-related pathologies, or are simply markers of brain ageing will be the subject of future studies.
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Ano de publicação:
1998
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Article