Ranitidine bismuth citrate with either clarithromycin 1 g/day or 1.5 g/day is equally effective in the eradication of H. pylori and healing of duodenal ulcer.
Aliment Pharmacol Ther
; 12(1): 63-8, 1998 Jan.
Article
em En
| MEDLINE
| ID: mdl-9692703
ABSTRACT
BACKGROUND:
No randomized double-blind studies have been performed to compare clarithromycin 1 g/day with higher doses of the macrolide (1.5 g/day) when combined with ranitidine bismuth citrate (RBC).AIM:
To compare H. pylori eradication and ulcer healing rates of RBC 400 mg b.d. for 4 weeks combined for the first 2 weeks either with clarithromycin 500 mg b.d. (Group A) or clarithromycin 500 mg t.d.s. (Group B).METHODS:
Two hundred and seventy-three patients with H. pylori-positive active duodenal ulcer were included. H. pylori infection was detected by CLO-test and histology on antral and corpus biopsies before and at least 4 weeks after the end of therapy. Eradication was assumed if both CLO-test and histology results were negative for H. pylori.RESULTS:
Eradication/healing rates according to intention-to-treat and per protocol analysis were 76/82% and 87/92% for Group A and 78/85% and 88/95% for Group B, respectively (P = N.S.). Adverse events were reported by 7% and 12% of patients in Groups A and B, respectively, and they were generally mild.CONCLUSIONS:
RBC in co-prescription with clarithromycin 500 mg b.d. is as effective as RBC plus clarithromycin 500 t.d.s. in eradicating H. pylori and healing duodenal ulcers.
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Base de dados:
MEDLINE
Assunto principal:
Ranitidina
/
Bismuto
/
Helicobacter pylori
/
Claritromicina
/
Úlcera Duodenal
/
Antagonistas dos Receptores H2 da Histamina
/
Antiulcerosos
/
Antibacterianos
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article