Mucosal morphological changes in the ileal neobladder.
Br J Urol
; 82(1): 114-7, 1998 Jul.
Article
em En
| MEDLINE
| ID: mdl-9698672
ABSTRACT
OBJECTIVE:
To determine the ultrastructural changes in the mucosa of intestinal segments used as a neobladder. MATERIALS ANDMETHODS:
Biopsy specimens from the ileal neobladders of eight men (mean age 62 years, range 52-68) who had undergone radical cystectomy were assessed by light and electron microscopy from 1 month to 5 years after operation. The morphology was compared with that in control specimens obtained from three patients of similar age during construction of an ileal neobladder after radical cystectomy.RESULTS:
Light microscopy showed shorter mucosal villi and fewer goblet cells. Marked oedema was found in all ileal neobladder walls. Electron microscopy revealed fewer and shorter microvilli and fewer filamentous core rootlets; cell borders were irregular, there were few senile cells in the tip of the villi and more desmosomes.CONCLUSIONS:
The absorptive and secretory function of the intestinal mucosa was probably decreased; the oedema of transferred ileal mucosa seemed to be associated with an inflammatory cell reaction. The cellular dynamics of the mucosa of the ileal neobladder changed with time, thus the ileal mucosa in the substitute bladder apparently adapted well to the new environment, i.e. urine retention, and neobladder expansion and contraction.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Coletores de Urina
/
Íleo
/
Mucosa Intestinal
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article