Syntheses and calcium channel antagonist activity of nifedipine analogues with methylsulfonylimidazolyl substituent.
Pharm Acta Helv
; 73(2): 75-9, 1998 Jul.
Article
em En
| MEDLINE
| ID: mdl-9700935
ABSTRACT
Various diester analogues of nifedipine in which the ortho nitrophenyl group at position 4 is replaced by 1-methyl-2-methylsulfonyl-5-imidazolyl substituent, were synthesized and evaluated as calcium channel antagonists on guinea-pig ileal smooth muscle. Nifedipine was used as a standard. Compound 6n was found to be the most active.
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Base de dados:
MEDLINE
Assunto principal:
Bloqueadores dos Canais de Cálcio
/
Nifedipino
/
Ácidos Nicotínicos
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article