5-HT3 receptors are not involved in conditioned taste aversions induced by 5-hydroxytryptamine, ipecacuanha or cisplatin.
Eur J Pharmacol
; 352(2-3): 143-9, 1998 Jul 10.
Article
em En
| MEDLINE
| ID: mdl-9716348
ABSTRACT
We have used the rat to examine the involvement of the 5-HT3 receptor in the mechanism(s) of conditioned taste aversion induced by 5-hydroxytryptamine (5-HT) and selected emetic drugs. 5-HT, ipecacuanha and cisplatin all induced conditioned taste aversion at doses known to induce emesis in other species but the responses were resistant to treatment with the 5-HT3 receptor antagonists ondansetron and granisetron. Further, m-chlorophenylbiguanide, a selective and potent 5-HT3 receptor agonist, failed to induce a conditioned taste aversion. The data provide strong evidence that the 5-HT3 receptor is not involved in conditioned taste aversion mechanisms in the rat. Results are discussed in terms of the usefulness of the rat conditioned taste aversion paradigm to anti-emetic research.
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Base de dados:
MEDLINE
Assunto principal:
Paladar
/
Serotonina
/
Receptores de Serotonina
/
Cisplatino
/
Ipeca
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article