Electromyographic effects of serotonin application into the lateral vestibular nucleus.
Neuroreport
; 9(11): 2539-43, 1998 Aug 03.
Article
em En
| MEDLINE
| ID: mdl-9721929
ABSTRACT
Electromyographic responses (EMGs) of limb muscles were studied during microiontophoretic application of 5-hydroxytryptamine (5-HT) into the lateral vestibular nucleus (LVN) or the spinal vestibular nucleus (SpVe) of anaesthetized rats. The aim was to ascertain whether the level of 5-HT in these nuclei was able to modulate muscle responsiveness. Increased levels of 5-HT in LVN (and to a weaker extent in SpVe) enhanced the EMGs of proximal extensor muscles and depressed those of flexors. The 5-HT2A receptor antagonist ketanserin, applied into the LVN, prevented 5-HT effects on EMG-evoked responses. It is concluded that 5-HT can modulate the motor output via the vestibulospinal pathway, exerting a differential control over flexor and extensor muscles.
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Base de dados:
MEDLINE
Assunto principal:
Núcleos Vestibulares
/
Serotonina
/
Eletromiografia
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article