[The empirical antibiotic therapy of patients with acute leukemias: the results of a multicenter study]. / Empiricheskaia antibioticheskaia terapiia u bol'nykh ostrymy leikozami: itogi mnogotsentrovogo issledovaniia.
Ter Arkh
; 70(7): 15-21, 1998.
Article
em Ru
| MEDLINE
| ID: mdl-9742629
ABSTRACT
AIM:
To evaluate efficacy of ampicilline/sulbactame and fluconasole in the regimen of empirical antibiotic therapy in patients with acute leukemia. MATERIALS ANDMETHODS:
The trial covered 14 hematological departments of Russia and 1 of Ukraine. Acute myeloid leukemia patients were included. 92 cases of fever in 56 patients with analysis of efficacy in 66 cases were considered. At the first stage of empirical antibiotic therapy, cefoperason (4 g/day) and gentamycin (240 mg/day) were administered. If no response was reached, ampicilline/sulbactam (7.5 g/day) was added. This was the second stage. If no response occurred for 5 days the three drugs were joined by fluconasol (400 mg followed by 200 mg).RESULTS:
Fever of unclear genesis was cured in 82% (28 of 34), clinical infection--in 80% (20 of 25), microbiologically confirmed infection--in 4 of 7 cases. A complete response to the empirical antibiotic therapy was registered in 52 of 66 cases (79%). 7(10.5%) patients died of infectious complications. 7(10.5%) received other antibiotics.
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Base de dados:
MEDLINE
Assunto principal:
Gentamicinas
/
Leucemia
/
Fluconazol
/
Cefoperazona
/
Cefalosporinas
/
Quimioterapia Combinada
/
Febre de Causa Desconhecida
/
Antibacterianos
Idioma:
Ru
Ano de publicação:
1998
Tipo de documento:
Article