The effect of combined nicotinamide and carbogen treatments in human tumour xenografts: oxygenation and tumour control studies.
Radiother Oncol
; 48(2): 143-8, 1998 Aug.
Article
em En
| MEDLINE
| ID: mdl-9783885
ABSTRACT
BACKGROUND AND PURPOSE:
This was an investigation to study the effect of giving carbogen and nicotinamide (CON) on pO2 and the radiation response of human xenografted tumours. MATERIALS ANDMETHODS:
The human xenografts were two sarcomas (ENE2 and ES3) and a glioblastoma (HTZ17). Nicotinamide (500 mg/ kg, i.p.) was administered 60 min before PO2 measurements and irradiation, while carbogen was given for 5 min before and during these treatments. Tumour pO2 was measured with an Eppendorf electrode and radiation response was assessed by local tumour control following irradiation with 10 daily fractions.RESULTS:
All three xenografts were found to be poorly oxygenated (about 80% of all pO2 values were < or =2.5 mmHg). CON treatment improved the oxygenation status in all three tumours such that 65, 52 and 71% of the pO2 values were < or =2.5 mmHg in ENE2, ES3 and HTZ17, respectively. However, only in ES3 was this decrease significant. The TCD50 doses for all tumours were around 52-54 Gy. No significant improvement was seen with CON in ENE2 (TCD50 = 48 Gy) and HTZ17 (TCD50 = 56 Gy), but for the ES3 xenograft a significant decrease to 42 Gy was found.CONCLUSIONS:
The three tumours used in this study appeared to show the same level of hypoxia as measured both by pO2 and radiation response. However, only one tumour showed a significant improvement after CON treatment, suggesting that not all hypoxic human tumours might benefit from this type of therapy.
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Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Consumo de Oxigênio
/
Radiossensibilizantes
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Sarcoma
/
Transplante Heterólogo
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Dióxido de Carbono
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Niacinamida
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Neurofibrossarcoma
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Glioblastoma
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Transplante de Neoplasias
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article