Cloning and sequence analysis of a lysophospholipase homologue from Schistosoma mansoni.
Parasitol Res
; 84(10): 839-42, 1998 Oct.
Article
em En
| MEDLINE
| ID: mdl-9797070
ABSTRACT
A novel cDNA encoding a lysophospholipase (SmLPLH) homologue has been cloned from the human parasite, Schistosoma mansoni. The predicted primary structure of SmLPLH shares high sequence homology with mammalian lysophospholipases (62%) and also contains aconsensus signature peptide (GXSXG), which is present in all lipases. Two splice variants of SmLPLH that differ by 32 N-terminal amino acids were identified. The shorter truncated species carries a conserved S. mansoni spliced leader (SL) sequence at its 5' end and is believed to be formed by trans-splicing of the SL to an internal exon splice site. The functional significance of these two isoforms of SmLPLH is currently unknown.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Schistosoma mansoni
/
Lisofosfolipase
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article