Effects of nimodipine on acute cerebral ischemia and reperfusion injury of rats.
Zhongguo Yao Li Xue Bao
; 17(4): 309-10, 1996 Jul.
Article
em En
| MEDLINE
| ID: mdl-9812709
ABSTRACT
AIM:
To study the effect of nimodipine (Nim) on ischemic cerebral damage.METHODS:
The four-vessel occlusion method was performed on rats. Monoamines were measured by fluorospectrophotometry.RESULTS:
Intraperitoneal injection of Nim 0.75 and 1.5 mg.kg-1 quickened the recovery of EEG changes to 19 +/- 3 and 17 +/- 4 min (P < 0.01), respectively. Nim reduced the decreases of monoamines (NE, DA, 5-HT, and 5-HIAA) contents after 30-min cerebral ischemia and 1-h reperfusion.CONCLUSION:
Nim protects the brain from ischemic damage.
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Base de dados:
MEDLINE
Assunto principal:
Bloqueadores dos Canais de Cálcio
/
Nimodipina
/
Traumatismo por Reperfusão
/
Isquemia Encefálica
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article