Metabolism of testosterone 4-14C in skin of castrated rats.
Arch Dermatol Res (1975)
; 256(3): 265-73, 1976 Oct 27.
Article
em En
| MEDLINE
| ID: mdl-984878
ABSTRACT
Testosterone metabolism was studied in the skin and preputial glands of normal and prepuberally castrated male rats during the 2nd hair cycle. In catagen-telogen the 17-beta-OHSDH of dorsal skin was higher in castrated than in control animals; 5-alpha-reductase instead, remained unchanged through out the hair cycle. Also in the preputial glands of castrated rats 17-beta-OHSDH was higher than in normal rats. So was 5-alpha-reductase. A possible direct control of a substrate, like Testosterone, and/or of a hypophyseal tropin, like prolactin, on enzymes that direct the metabolism of steroids in target tissues is conceivable.
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Base de dados:
MEDLINE
Assunto principal:
Pele
/
Testosterona
/
Castração
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Article