Variable distribution of TFF2 (Spasmolysin) alleles in Europeans does not indicate predisposition to gastric cancer.
Hum Hered
; 49(1): 45-7, 1999 Jan.
Article
em En
| MEDLINE
| ID: mdl-9858857
ABSTRACT
Peptides belonging to the trefoil factor family (TFF) protect the gastrointestinal epithelia. Overexpression of TFFs was observed in pathological conditions such as gastritis, ulceration, metaplasia and neoplasia of the gastrointestinal tract. The aims of this work were to investigate the recently described TFF2 gene polymorphism in different European populations. DNA samples from blood of healthy individuals and gastric cancer patients were genotyped using the polymerase chain reaction. They were compared to a gastric cancer population. The results do not show any significant difference in allelic frequencies between gastric cancer patients and healthy individuals from Portugal. However, the frequency of the two alleles found varies considerably among Europeans.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Polimorfismo Genético
/
Neoplasias Gástricas
/
Neuropeptídeos
/
Substâncias de Crescimento
/
Frequência do Gene
/
Mucinas
/
Proteínas Musculares
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article