The integration host factor (IHF) affects the expression of the phosphate-binding protein and of alkaline phosphatase in Escherichia coli.
Curr Microbiol
; 38(2): 80-5, 1999 Feb.
Article
em En
| MEDLINE
| ID: mdl-9871104
ABSTRACT
The genes encoding alkaline phosphatase (phoA) and the inducible inorganic phosphate transport system Pst (pstS,C,A,B,U) belong to the PHO regulon. Mutants of Escherichia coli lacking the global regulatory protein integration host factor (IHF) show an increased level of alkaline phosphatase and a decreased level of Pst. IHF binds weakly but specifically to a DNA fragment containing the promoter region of the pst operon but does not bind to a fragment that includes the promoter region of phoA. It is proposed that IHF is a positive regulator of the pst operon and as such controls indirectly the expression of phoA.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Proteínas de Transporte
/
Regulação Bacteriana da Expressão Gênica
/
Fosfatase Alcalina
/
Escherichia coli
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article