The structure-activity relationships of a series of suicide inhibitors of phospholipase A2.
Bioorg Med Chem Lett
; 8(16): 2129-32, 1998 Aug 18.
Article
em En
| MEDLINE
| ID: mdl-9873499
ABSTRACT
A series of mechanism-based inhibitors of phospholipase A2 (SIBLINKS) were synthesized. These new SIBLINKS are phospholipid analogues that contain a para-substituted phenyl 3,3-dimethylglutaryl group in the place of the sn-2 acyl chain. The effect of the phenyl leaving group on inhibitory activity was studied by varying the electron-withdrawing ability of the para-substituted group. A strong correlation was observed between the leaving group potential of the suicide inhibitor and the inhibitory activity of the derivative toward cobra venom phospholipase A2.
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Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Fosfolipases A
/
Fosfolipídeos
/
Inibidores Enzimáticos
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article