H-phosphonate derivatives as novel peptide deformylase inhibitors.
Bioorg Med Chem Lett
; 8(18): 2479-82, 1998 Sep 22.
Article
em En
| MEDLINE
| ID: mdl-9873565
ABSTRACT
Peptide deformylase catalyzes the removal of the N-terminal formyl group from nascent polypeptides during prokaryotic protein maturation and is essential for bacterial survival. Its absence from eukaryotic organisms makes it an attractive target for designing novel antibacterial agents. Peptidyl H-phosphonates were synthesized and shown to be competitive inhibitors of the deformylase.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores Enzimáticos
/
Organofosfonatos
/
Amidoidrolases
/
Aminopeptidases
/
Anti-Infecciosos
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article