Isolation and identification of inhibitory compounds on TNF-alpha production from Magnolia fargesii.
Arch Pharm Res
; 21(1): 67-9, 1998 Feb.
Article
em En
| MEDLINE
| ID: mdl-9875517
ABSTRACT
Three TNF alpha-inhibitory lignans were isolated from the flower buds of Magnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF-alpha production in LPS-stimulated murine macrophage cell line, RAW264.7 and eudesmin showed the strongest activity (IC50 = 51 microM).
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Fator de Necrose Tumoral alfa
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article