Bio-active cardenolides from the leaves of Nerium oleander.
Phytochemistry
; 50(3): 435-8, 1999 Feb.
Article
em En
| MEDLINE
| ID: mdl-9933955
ABSTRACT
A bioactivity directed isolation of the methanolic extract of the fresh, uncrushed leaves of Nerium oleander showing a central nervous system (CNS) depressant effect in mice has been undertaken. As a result, four CNS depressant cardenolides including a new cardenolide, neridiginoside and three known constituents, nerizoside, neritaloside and odoroside-H, have been isolated which exhibited CNS depressant activity in mice at a dose of 25 mg/kg. The structure of neridiginoside was elucidated as 3 beta-O-(D-diginosyl)-5 beta, 14 beta-dihydroxy-card-20(22)-enolide, using spectroscopic methods including one-dimensional and two-dimensional NMR (COSY-45, NOESY, J-resolved, HMQC and HMBC). The known compounds have been indentified through spectral studies and comparison of data with those reported in the literature.
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Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Cardenolídeos
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article