Modulation of nitric oxide production by tetracyclines and chemically modified tetracyclines.
Adv Dent Res
; 12(2): 126-30, 1998 Nov.
Article
em En
| MEDLINE
| ID: mdl-9972136
ABSTRACT
Chemically modified tetracyclines (CMTs) dose-dependently decreased inducible nitric oxide synthase (iNOS) and, consequently, nitric oxide (NO) formation by the lipopolysaccharide (LPS)-stimulated J774 line. The inhibitory effect was due to a specific reduction in the iNOS protein content in the cells, as attested by Western blot analysis and by the inhibition of iNOS mRNA accumulation. Furthermore, CMTs cause a dose-dependent increase in cell death in the J774 line mediated by the NO-independent apoptotic mechanism.
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Base de dados:
MEDLINE
Assunto principal:
Tetraciclinas
/
Óxido Nítrico Sintase
/
Macrófagos
/
Óxido Nítrico
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article